TPMT Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD252714A
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TPMT Polyclonal Antibody at dilution of 1:60(×200)
Product Name
TPMT Polyclonal Antibody
Catalog Number
RD252714A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Immunogen Information
Immunogen
Fusion protein of human TPMT
Swissprot
P51580
Synonyms
HGNC:12014S adenosyl L methionine thiopurine S methyltransferaseThiopurine methyltransferaseThiopurine S methyltransferaseThiopurine S-methyltransferaseTPMTTPMT
Gene Accession
BC005339
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:40-1:200, ELISA 1:5000-1:10000
Concentration
1.08 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas