TPMT Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD266207A
Immunofluorescence analysis of U2OS cells using TPMT Polyclonal Antibody
Product Name
TPMT Polyclonal Antibody
Catalog Number
RD266207A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Immunogen Information
Immunogen
Recombinant fusion protein of human TPMT (NP_000358.1).
Gene ID
7172
Swissprot
P51580
Synonyms
TPMTTPMTD
Applications
Reactivity
Human,Mouse
Tested Applications
IF
Conjugation
Unconjugated
Dilution
IF 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas