This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Immunogen Information
Immunogen
Recombinant protein of human TRAF3IP2
Swissprot
O43734
Synonyms
Act 1ACT1Activator of cAMP responsive element modulator (CREM) in testisAdapter protein CIKSC6ORF4C6ORF5C6ORF6Chromosome 6 Open Reading Frame 4Chromosome 6 Open Reading Frame 5Chromosome 6 Open Reading Frame 6CIKSConnection to IKK and SAPK / JN
Calculated MW
65 kDa
Gene Accession
BC002823
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4