The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants.
Immunogen Information
Immunogen
Full length fusion protein
Swissprot
Q96RU7
Synonyms
C20orf97Neuronal cell death inducible putative kinaseNeuronal cell death-inducible putative kinaseNIPKp65 interacting inhibitor of NF-kappaBp65-interacting inhibitor of NF-kappa-BSINKSKIP 3SKIP3TRB 3TRB-3TRB3TRIB 3Trib3TRIB3Tribbles homolog
Gene Accession
BC019363
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-150, ELISA 1:2000-10000
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4