The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
Immunogen Information
Immunogen
Fusion protein of human TRIM23
Swissprot
P36406
Synonyms
ADP ribosylation factor domain protein 1ADP-ribosylation factor domain-containing protein 1ARF domain protein 1ARFD1E3 ubiquitin-protein ligase TRIM23GTP binding protein ARD 1GTP-binding protein ARD-1N-acetyltransferase ARD1 human homolog ofN-acet