This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
Immunogen Information
Immunogen
Fusion protein of human TRIM27
Swissprot
P14373
Synonyms
AW538890DAAP-182E11.3MGC189472OTTHUMP00000029314Ret finger proteinRFPRFP transforming proteinRfp1RING finger protein 76RNF76TRI27TRIM 27Trim27Tripartite motif containing 27Tripartite motif containing protein 27Tripartite motif protein TRIM2