Activating signal co-integrator-1 (ASC-1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASC-1 functions with the transcription integrators SRC-1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASC-1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASC-1 localizes to the cytoplasm.
Immunogen Information
Immunogen
Recombinant protein of human TRIP4
Swissprot
Q15650
Synonyms
Activating signal cointegrator 1ASC 1ASC-1HsT17391Thyroid hormone receptor interactor 4Thyroid receptor interacting protein 4Thyroid receptor-interacting protein 4TR-interacting protein 4TRIP 4TRIP-4Trip4TRIP4ZC2HC5Zinc finger C2HC5 type
Calculated MW
66 kDa
Gene Accession
BC012448
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4