This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).
Immunogen Information
Immunogen
Recombinant human Activating signal cointegrator 1 protein
Swissprot
Q15650
Synonyms
Activating signal cointegrator 1ASC 1ASC-1HsT17391Thyroid hormone receptor interactor 4Thyroid receptor interacting protein 4Thyroid receptor-interacting protein 4TR-interacting protein 4TRIP 4TRIP-4Trip4TRIP4ZC2HC5Zinc finger C2HC5 type
Calculated MW
66 kDa
Observed MW
66 kDa
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC
Conjugation
Unconjugated
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Concentration
2 mg/mL
Storage Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.