The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Immunogen Information
Immunogen
Synthetic peptide of human TRPC6
Swissprot
Q9Y210
Synonyms
bZ1P14.9FLJ11098FLJ14863FSGS2MTRP6Short transient receptor potential channel 6si:rp71-1p14.9Transient receptor potential cation channel subfamily C member 6Transient receptor protein 6TRP 6TRP-6TRP6TRPC 6Trpc6TRPC6TRRP6
Gene Accession
NP_004612
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4