TTLL12 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD89393A
Western blot analysis of extracts of various cell lines using TTLL12 Polyclonal Antibody at 1:1000 dilution.
Variation
Quantity
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Overview
Product Name
TTLL12 Polyclonal Antibody
Catalog Number
RD89393A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3. Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
Immunogen Information
Immunogen
Recombinant fusion protein of human TTLL12
Gene ID
23170
Swissprot
Q14166
Synonyms
TTLL12dJ526I14.2tubulin tyrosine ligase like 12
Calculated MW
31kDa/37kDa/42kDa/44kDa/52kDa
Observed MW
Refer to figures
Applications
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.