This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.TUBGCP4 (Tubulin Gamma Complex Associated Protein 4) is a Protein Coding gene. Diseases associated with TUBGCP4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 3 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP6.
Immunogen Information
Immunogen
Fusion protein of human TUBGCP4
Swissprot
Q9UGJ1
Synonyms
76PFLJ14797Gamma tubulin complex component 4Gamma tubulin ring complex protein (76p gene)Gamma tubulin ring complex proteinGamma-ring complex protein 76 kDaGCP 4GCP4Grip76h76phGCP4Hgrip76TUBGCP 4TUBGCP4Tubulin gamma complex associated protei