TXK Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD87999A
Western blot analysis of extracts of rat thymus using TXK Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of rat thymus using TXK Polyclonal Antibody at 1:1000 dilution.
Variation
Quantity
Add to Cart

For more information on our kits, please contact us at info@reddotbiotech.com

Overview
Circle
Product Name
TXK Polyclonal Antibody
Catalog Number
RD87999A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Circle
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC activate T-cell receptor (TCR, a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
Immunogen Information
Circle
Immunogen
Recombinant fusion protein of human TXK
Gene ID
7294
Swissprot
P42681
Synonyms
TXKBTKLPSCTK5PTK4RLKTKL
Calculated MW
11kDa/12kDa
Observed MW
12kDa
Applications
Circle
Reactivity
Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Your item has been successfully added to your cart .

Item # Price
Proceed to Cart

Never miss an update.

Sign up for our monthly newsletter to hear about exclusive sales and product tips and tricks.