TYROBP Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88000A
Western blot analysis of extracts of mouse pancreas using TYROBP Polyclonal Antibody at 1:3000 dilution.
Western blot analysis of extracts of mouse pancreas using TYROBP Polyclonal Antibody at 1:3000 dilution.
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Overview

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Product Name
TYROBP Polyclonal Antibody
Catalog Number
RD88000A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Immunogen Information

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Immunogen
A synthetic peptide of human TYROBP
Gene ID
7305
Swissprot
O43914
Synonyms
TYROBPDAP12KARAPPLOSL
Calculated MW
25kDa
Observed MW
26kDa

Applications

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Reactivity
Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Research Areas

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