Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Immunogen Information
Immunogen
Fusion protein of human UACA
Swissprot
Q9BZF9
Synonyms
FLJ10128KIAA1561MGC141967MGC141969Nuclear membrane binding proteinNUCLINGUACAUACAUveal autoantigen with coiled coil domains and ankyrin repeatsUveal autoantigen with coiled-coil domains and ankyrin repeats
Gene Accession
BC113407
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-150, ELISA 1:2000-10000
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4