The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human UBE4B
Swissprot
O95155
Synonyms
4930551I19Rik4933406G05RikAU014668D4Bwg0973eE4HDNB1Homozygously deleted in neuroblastoma 1KIAA0684mKIAA0684RP23 173D8.1Ube4bUBE4BUbiquitin conjugation factor E4 BUbiquitin fusion degradation protein 2UBOX3UFD2UFD2aUfd2p