UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Immunogen Information
Immunogen
Fusion protein of human UGT2B4
Swissprot
P06133
Synonyms
EC 2.4.1.17HLUG25Hyodeoxycholic acidHyodeoxycholic acid specific UDPGTUDP glucuronosyltransferase 2 family polypeptide B4UDP glucuronosyltransferase 2B4UDP glucuronosyltransferase 2B4 precursorUDP glucuronyltransferase family 2 beta 4UDP glycosylt
Gene Accession
BC026264
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-150, ELISA 1:2000-10000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4