This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
Immunogen Information
Immunogen
Synthetic peptide of human UHRF2
Swissprot
Q96PU4
Synonyms
DKFZp434B0920DKFZp686G0837E3 ubiquitin-protein ligase UHRF2MGC33463Np95 like RING finger proteinNp95-like ring finger proteinNp95/ICBP90 like RING finger proteinNp95/ICBP90-like RING finger proteinNuclear protein 97Nuclear zinc finger protein Np9
Gene Accession
NP_690856
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4