The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Fusion protein of human USO1
Swissprot
O60763
Synonyms
General vesicular transport factorGeneral vesicular transport factor p115P115Protein USO1 homologTAPTranscytosis associated proteinTranscytosis-associated proteinUso1USO1VDPVesicle docking proteinVesicle-docking protein