This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Immunogen Information
Immunogen
Recombinant protein of human USP2
Swissprot
O75604
Synonyms
41 kDa ubiquitin specific protease41 kDa ubiquitin-specific proteaseDeubiquitinating enzyme 2Ubiquitin carboxyl terminal hydrolase 2Ubiquitin carboxyl-terminal hydrolase 2ubiquitin specific peptidase 2Ubiquitin specific processing protease 2Ubiquit
Gene Accession
BC002854
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4