USP37 (ubiquitin specific peptidase 37) is a 979 amino acid protein that contains three UIM (ubiquitin-interacting motif) repeats and belongs to thepeptidase C19 family. Expressed in prostate and brain tissue, USP37 functions to catalyze the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP37 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.