VWA5A Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD77888A
Western Blot analysis of adrenal pheochromocytoma tissue,Jurkat and A549 cell    using VWA5A Polyclonal Antibody at dilution of 1:275
Western Blot analysis of adrenal pheochromocytoma tissue,Jurkat and A549 cell using VWA5A Polyclonal Antibody at dilution of 1:275
Immunohistochemistry of paraffin-embedded Human lung cancer using VWA5A Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human lung cancer using VWA5A Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human liver cancer using VWA5A Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human liver cancer using VWA5A Polyclonal Antibody at dilution of 1:60
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Overview

Circle
Product Name
VWA5A Polyclonal Antibody
Catalog Number
RD77888A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.

Immunogen Information

Circle
Immunogen
Recombinant protein of human VWA5A
Swissprot
O00534
Synonyms
BCSC1BCSC-1LOH11CR2A
Calculated MW
86 kDa
Gene Accession
BC001234

Applications

Circle
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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