This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
Immunogen Information
Immunogen
Synthetic peptide of human WNK4
Swissprot
Q96J92
Synonyms
PHA 2BPHA2BPRKWNK 4PRKWNK4Protein kinase lysine deficient 4Protein kinase lysine-deficient 4Protein kinase with no lysine 4Serine/threonine protein kinase WNK4Serine/threonine-protein kinase WNK4WNK lysine deficient protein kinase 4Wnk4WNK4