WRN Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD253558A
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue  using WRN Polyclonal Antibody at dilution of 1:55(×200)
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using WRN Polyclonal Antibody at dilution of 1:55(×200)
Immunohistochemistry of paraffin-embedded Human breast cancer tissue  using WRN Polyclonal Antibody at dilution of 1:55(×200)
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using WRN Polyclonal Antibody at dilution of 1:55(×200)
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Overview

Circle
Product Name
WRN Polyclonal Antibody
Catalog Number
RD253558A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit

Background

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This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Immunogen Information

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Immunogen
Synthetic peptide of human WRN
Swissprot
Q14191
Synonyms
DKFZp686C2056DNA helicaseDNA helicaseRecQ like type 3Exonuclease WRNHGNC 12791OTTHUMP00000225301RecQ protein-like 2RecQ-like type 3RecQ3RECQL2RECQL3Werner syndrome ATP-dependent helicaseWerner syndrome helicaseWerner syndrome proteinWerner
Gene Accession
NP000544

Applications

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Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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