The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human XPC
Swissprot
Q01831
Synonyms
DNA repair protein complementing XP C cellsDNA repair protein complementing XP-C cellsDNA repair protein complementing XPC cellsp125RAD4Xeroderma pigmentosum complementation group CXeroderma pigmentosum group C complementing proteinXeroderma pigme