YBX1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD253542A
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using YBX1 Polyclonal Antibody at dilution of 1:25(×200)
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using YBX1 Polyclonal Antibody at dilution of 1:25(×200)
Product Name
YBX1 Polyclonal Antibody
Catalog Number
RD253542A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This protein mediates pre-mRNA alternative splicing regulation. It binds to splice sites in pre-mRNA and regulates splice site selection and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It can regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro).
Immunogen Information
Immunogen
Synthetic peptide of human YBX1
Swissprot
P67809
Synonyms
BP 8CBF-ACCAAT binding transcription factor I subunit ACCAAT-binding transcription factor I subunit ACSDA2CSDBDBPBDNA binding protein BDNA-binding protein BEFI-AEnhancer factor I subunit AMDR NF1MGC104858MGC110976MGC117250NSEP 1NSEP1Nucle
Gene Accession
NP004550
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.