Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 5 (ZBTB5) is a 677 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB5 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain suggest that ZBTB5 functions as a transcription regulator.
Immunogen Information
Immunogen
Fusion protein of human ZBTB5
Swissprot
O15062
Synonyms
5930421I109430083K24RikAI646847Expressed in brain and neural tubeKIAA0354mKIAA0354OTTMUSP00000007812OTTMUSP00000007813OTTMUSP00000007814RP11-397D12.5RP23-218A4.2Transcription factor ZNF POZZbtb5ZBTB5Zinc finger and BTB domain containing prot
Calculated MW
74 kDa
Observed MW
Refer to figures
Gene Accession
BC010007
Applications
Reactivity
Human, Mouse
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:10000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
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