This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.
Immunogen Information
Immunogen
Fusion protein of human ZFYVE27
Swissprot
Q5T4F4
Synonyms
ProtrudinRP11 459F3.2SPG33ZFY27ZFYVE27zinc finger FYVE domain containing 27Zinc finger FYVE domain containing protein 27Zinc finger FYVE domain-containing protein 27