ZNF354A Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD218464A
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ZNF354A Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human tonsil tissue using ZNF354A Polyclonal Antibody at dilution of 1:40(×200)
Product Name
ZNF354A Polyclonal Antibody
Catalog Number
RD218464A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.
Immunogen Information
Immunogen
Fusion protein of human ZNF354A
Swissprot
O60765
Synonyms
EZNFHKL1HLK1Homo sapiens zinc finger protein 354AKID 1KID1Kidneyischemiaand developmentally regulated protein 1Renal transcription factor Kid 1TCF-17TCF17Transcription factor 17Z354AZinc finger protein 354AZinc finger protein eZNFZNF354
Gene Accession
BC047105
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas