ZNF451 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD266483A
Western blot analysis of extracts of various cell lines using ZNF451 Polyclonal Antibody at dilution of 1:1000.
Product Name
ZNF451 Polyclonal Antibody
Catalog Number
RD266483A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
Immunogen Information
Immunogen
Recombinant fusion protein of human ZNF451 (NP_001026794.1).
Gene ID
26036
Swissprot
Q9Y4E5
Synonyms
ZNF451COASTERdJ417I1.1
Calculated MW
63 kDa/115 kDa/121 kDa
Observed MW
Refer to figures
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:200-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.