α-Actinin-4 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88543A
Western blot analysis of extracts of various cell lines using α-Actinin-4 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using α-Actinin-4 Polyclonal Antibody at 1:1000 dilution.
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Overview

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Product Name
α-Actinin-4 Polyclonal Antibody
Catalog Number
RD88543A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Immunogen Information

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Immunogen
Recombinant fusion protein of human α-Actinin-4
Gene ID
81
Swissprot
O43707
Synonyms
ACTN4ACTININ-4FSGSFSGS1
Calculated MW
28kDa
Observed MW
28kDa

Applications

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Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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